Tricyclic Antidepressants (TCA)

What is it?

Tricyclic antidepressants aids against depression by changing the process which neurotransmitters in the brain are normally received. These antidepressants block the absorption of specific chemical messengers serotonin and norepinephrine in the brain. By blocking the absorption, these messengers will be more available in the brain which may help the brain transmit and interpret messages better, ultimately creating better moods.

Names of Drugs:

  • Amitriptyline
  • Amoxapine
  • Desipramine
  • Doxepin
  • Imipramine[1]

What are the health risks?

Short Term Effects:

  • Dry mouth
  • Slight blurring of vision
  • Constipation
  • Drowsiness
  • Dizziness





Long Term Effects:

  • Higher risk of diabetes
  • Weight gain[2]


How is it used?


Tricyclic antidepressants are usually ingested orally in the form of pills.